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Delta Sleep-Inducing Peptide (DSIP)
Also known as: Delta Sleep Inducing Peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Confidence
Updated 2026-03-18
DSIP is a naturally occurring nonapeptide originally isolated from rabbit brain during electrically induced sleep. It modulates sleep architecture, stress response, and pain perception. Despite decades of research since its discovery in 1977, its precise mechanism remains poorly understood, and it has never achieved regulatory approval anywhere. It remains popular in peptide therapy circles for sleep optimization.
Class
Sleep / Recovery Peptide
Routes
Subcutaneous, Intravenous, Intranasal
Half-Life
~15–25 minutes (extremely rapid degradation in plasma)
DSIP's mechanism is incompletely understood. It appears to modulate sleep by influencing GABAergic, serotonergic, and glutamatergic neurotransmission. It promotes delta (slow-wave) sleep stages, reduces cortisol and ACTH (stress axis modulation), modulates LH release (reproductive effects), and may influence endorphin/enkephalin systems (pain modulation). It does not act as a classical sedative — rather, it appears to normalize disrupted sleep architecture.
Half-Life
~15–25 minutes (extremely rapid degradation in plasma)
Bioavailability
Not well established. Very short plasma half-life suggests rapid clearance. Intranasal and IV routes studied.
No approved indications. Research: insomnia, sleep architecture disruption, stress-related sleep disorders, chronic pain, opiate withdrawal, narcolepsy.
Research dating to the 1970s-1990s showed DSIP promotes delta sleep in EEG studies, normalizes disturbed sleep in insomniacs, and reduces withdrawal symptoms in opiate dependence. However, results have been inconsistent across studies. Some researchers have failed to replicate sleep-promoting effects. A Swiss study in chronic insomnia patients showed improved subjective sleep quality. The field is characterized by intriguing preliminary data but lack of definitive large-scale trials.
Human Studies
15
Animal Studies
40
Generally well-tolerated in published studies. No significant adverse effects reported. Very short half-life limits systemic exposure. No reported dependency. Inconsistent efficacy is the primary concern rather than safety. Purity of commercially available DSIP is a practical concern.
Investigational. Never approved in any country despite decades of research. Available through research peptide suppliers. Not controlled or scheduled.
Drug Interactions: Theoretical interactions with GABAergic drugs, sleep medications, corticosteroids. Monitoring: Sleep quality assessment (subjective and/or polysomnography). Cortisol levels. Research Gaps: Mechanism of action still poorly understood. Inconsistent replication of results. No standardized dosing protocol. Very short half-life may limit efficacy — depot or modified-release formulations may be needed.
Subcutaneous (research context)
Common Range
100–300 mcg before bedtime
Timing
30 minutes before bedtime
Frequency
Nightly or 3–5 times per week
Cycling
2–4 weeks
Reconstitution
Reconstitute lyophilized powder with bacteriostatic water
Storage
Refrigerated after reconstitution. Sensitive to degradation.
Important Note
NOT FDA-approved. Inconsistent research results. Very short half-life. Purity varies among suppliers. Research context only.
Connect with a verified provider offering DSIP therapy near you.
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Nootropic / Anxiolytic Peptide
Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin, with an added Pro-Gly-Pro sequence for stability. Developed at the Institute of Molecular Genetics (Russian Academy of Sciences), it is approved in Russia as an anxiolytic and nootropic. It exhibits both anxiolytic and cognitive-enhancing properties without sedation or addiction potential.
Disclaimer: This content is for educational and informational purposes only and does not constitute medical advice. Always consult with a licensed healthcare provider before starting, stopping, or modifying any peptide therapy. PeptideSupplierMatch does not prescribe, sell, or distribute peptides.
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