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Sermorelin Acetate
Also known as: Geref, GHRH(1-29)
Confidence
Updated 2026-03-18
Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids of the 44-amino acid GHRH sequence. Originally FDA-approved for diagnostic use in assessing growth hormone secretion, it has become a cornerstone of legitimate peptide therapy for growth hormone optimization due to its established safety profile and compounding eligibility.
Class
GHRH Analog
Routes
Subcutaneous
Half-Life
10–20 minutes
Sermorelin stimulates the anterior pituitary gland to produce and secrete growth hormone in a pulsatile, physiologic pattern. Unlike exogenous HGH injections that bypass the hypothalamic-pituitary axis, sermorelin works within the body's natural feedback systems, preserving normal regulatory control and reducing the risk of supraphysiologic GH levels.
Half-Life
10–20 minutes
Bioavailability
Subcutaneous: ~5–10% (rapidly degraded)
Diagnostic assessment of growth hormone secretion. Off-label: growth hormone optimization, anti-aging protocols, body composition improvement, sleep quality, recovery support.
Clinical data primarily from diagnostic use studies and small-scale clinical investigations. Well-established pharmacological profile from original FDA approval process. Limited large-scale RCTs for off-label indications. Safety profile well-characterized through decades of clinical use.
Human Studies
30
Animal Studies
50
Generally well-tolerated. Common: injection site reactions, facial flushing, headache. Rare: dizziness, hyperactivity. Contraindicated in active malignancy (theoretical growth promotion). Should not be used concurrently with exogenous HGH.
Component of FDA-approved drug (Geref, discontinued 2008 for commercial reasons). Eligible for 503A compounding with valid prescription. One of the few GH-axis peptides with clear legal compounding pathway.
Drug Interactions: Concurrent use with glucocorticoids may blunt GH response. Should not be combined with exogenous HGH. Monitoring: IGF-1 levels at baseline and during therapy. Research Gaps: Limited head-to-head data against other GH secretagogues. Long-term outcomes in anti-aging applications not well-studied.
Subcutaneous
Common Range
200–500 mcg/day
Timing
Before bed (fasted state preferred)
Frequency
5–7 days/week
Cycling
8–12 weeks on, 4 weeks off (common protocol)
Reconstitution
Bacteriostatic water
Storage
Refrigerated after reconstitution (2–8°C)
Important Note
Evening administration aligns with natural GH pulse during sleep. Start at lower end and titrate based on IGF-1 response.
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GH Secretagogue
CJC-1295 is a synthetic analog of GHRH(1-29) with modifications to extend its half-life. Available in two forms: with Drug Affinity Complex (DAC) for prolonged action, and without DAC (also called Modified GRF 1-29) for shorter, more pulsatile action. Frequently combined with ipamorelin for synergistic GH release.
GH Secretagogue
Ipamorelin is a selective growth hormone secretagogue that mimics ghrelin to stimulate GH release from the pituitary. It is considered one of the most selective GH secretagogues, with minimal effect on cortisol, prolactin, and other hormones — making it a preferred choice in combination protocols with CJC-1295.
GHRH Analog
Tesamorelin is a synthetic GHRH analog that is the only FDA-approved peptide therapy specifically for the reduction of excess abdominal fat. Originally approved for HIV-associated lipodystrophy, it has gained significant attention in the anti-aging and metabolic optimization space as a legal, well-characterized GH secretagogue.
Disclaimer: This content is for educational and informational purposes only and does not constitute medical advice. Always consult with a licensed healthcare provider before starting, stopping, or modifying any peptide therapy. PeptideSupplierMatch does not prescribe, sell, or distribute peptides.
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