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Thymosin Beta-4 Fragment (TB-500)
Also known as: TB500, Thymosin β4 Fragment, Tβ4
Confidence
Updated 2026-03-18
TB-500 is a synthetic version of thymosin beta-4, a naturally occurring 43-amino acid protein fragment that plays critical roles in tissue repair, cell migration, and anti-inflammatory processes. Combined with BPC-157, it forms what is colloquially known as "the Wolverine stack" in regenerative wellness circles. Like BPC-157, its clinical evidence base is limited to preclinical data.
Class
Tissue Repair & Regeneration
Routes
Subcutaneous, Intramuscular
Half-Life
Not established in humans (estimated hours based on animal pharmacokinetics)
TB-500 promotes cell migration and proliferation by upregulating actin, a key protein in cell structure and movement. It facilitates wound healing by promoting angiogenesis, reducing inflammation, and protecting cells from further damage through anti-microbial and anti-inflammatory pathways. It may also influence hair follicle stem cell migration.
Half-Life
Not established in humans (estimated hours based on animal pharmacokinetics)
Bioavailability
Not established in humans.
No approved human indications. Preclinical research areas: wound healing, cardiac repair post-injury, muscle and tendon repair, hair growth, corneal healing.
Preclinical data shows consistent wound healing and tissue repair effects. Some early-stage human studies on thymosin beta-4 (not TB-500 specifically) in cardiac repair and dry eye. Laboratory studies suggest thymosin beta-4 may play a role in colorectal and pancreatic cancer cell migration — a significant safety concern. No completed human RCTs for TB-500.
Human Studies
3
Animal Studies
40
Limited human safety data. Theoretical concerns: immunogenicity, potential promotion of cancer cell migration (VEGF pathway activation, role in colorectal/pancreatic cancer spread observed in lab studies). Unknown long-term effects. Banned by WADA.
FDA Category 2 (September 2023). Cannot be compounded for human use. Not FDA-approved. Products sold as research chemicals only.
Recent Regulatory Activity
Drug Interactions: No clinical data. Theoretical interaction with anti-angiogenic therapies. Research Gaps: Cancer safety concern is the dominant research gap. Long-term human safety completely unknown.
Subcutaneous (research context)
Common Range
2–5 mg per dose
Timing
Twice weekly (loading), once weekly (maintenance)
Frequency
1–2x weekly
Cycling
Loading: 2x/week for 4–6 weeks; Maintenance: 1x/week or 2x/month
Reconstitution
Bacteriostatic water
Storage
Refrigerated after reconstitution
Important Note
NOT FDA-approved. Cannot be legally compounded. Research dosing only.
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Tissue Repair & Regeneration
BPC-157 is a synthetic pentadecapeptide derived from a protective protein found in human gastric juice. It has generated extraordinary interest for its broad cytoprotective and regenerative effects observed in preclinical studies across virtually every organ system studied. Despite this promise, it remains one of the most controversial peptides due to the near-complete absence of human clinical trial data.
Tissue Repair / Anti-Aging
GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. Levels decline significantly with age (from ~200 ng/mL at age 20 to ~80 ng/mL at age 60). It has gained attention for its broad biological activities including wound healing, anti-inflammatory effects, collagen synthesis, and potential gene expression modulation.
Disclaimer: This content is for educational and informational purposes only and does not constitute medical advice. Always consult with a licensed healthcare provider before starting, stopping, or modifying any peptide therapy. PeptideSupplierMatch does not prescribe, sell, or distribute peptides.
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