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Pinealon (Glu-Asp-Arg Bioregulator Peptide)
Also known as: EDR Peptide, Glu-Asp-Arg, EDR
Confidence
Updated 2026-03-20
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the St. Petersburg Institute of Bioregulation and Gerontology under Professor Vladimir Khavinson. It is part of the Khavinson bioregulator peptide family — short peptides claimed to regulate gene expression in specific tissues. Pinealon targets the pineal gland and central nervous system, with proposed neuroprotective and circadian rhythm-modulating effects. It is approved in Russia as a dietary bioregulator supplement.
Class
Bioregulator Peptide
Routes
Oral, Sublingual, Subcutaneous
Half-Life
Short — minutes (typical of tripeptides); proposed to exert effects through gene expression changes that outlast peptide presence
Pinealon is proposed to penetrate cell membranes and interact with DNA, selectively regulating gene expression in pineal gland and neural tissues. Khavinson's bioregulation theory posits that short peptides (2–4 amino acids) can epigenetically modulate tissue-specific gene expression. Proposed mechanisms include upregulation of melatonin synthesis enzymes (AANAT, ASMT) in pinealocytes, neuroprotective gene activation, and modulation of serotonin-melatonin pathway. It may also influence circadian clock gene expression.
Half-Life
Short — minutes (typical of tripeptides); proposed to exert effects through gene expression changes that outlast peptide presence
Bioavailability
Oral/sublingual: uncertain; claimed to be bioactive orally due to small size. Subcutaneous: moderate.
Russian-approved: brain bioregulation, neuroprotection, sleep optimization. No Western-approved indications. Research interest: pineal gland support, melatonin production optimization, circadian rhythm disorders, age-related cognitive decline, neuroprotection.
Khavinson et al. have published multiple studies on bioregulator peptides in Russian and international journals. Pinealon has been shown to increase melatonin production in pinealocyte cell cultures and demonstrate neuroprotective effects in animal models of brain injury. Anisimov et al. reported lifespan extension in animal studies with various bioregulator peptides. However, most studies come from the original research group, and independent Western replication is limited. The bioregulation theory (short peptides directly modulating gene expression) remains controversial and not widely accepted in mainstream pharmacology.
Human Studies
5
Animal Studies
15
No significant adverse effects reported in Russian clinical use or published studies. As a naturally occurring tripeptide sequence, toxicity risk is considered low. Long-term safety data limited to Russian post-market surveillance. No Western safety evaluation conducted.
Approved in Russia as part of the Khavinson bioregulator peptide family. Available from Russian and international peptide suppliers. Not FDA-approved. Not on any Western regulatory pathway. Companion bioregulator peptides include Epitalon (pineal/telomerase), Thymalin (thymus), Cortexin (cortex), and Retinalamin (retina).
Drug Interactions: No established interactions. Theoretical: may potentiate melatonin or melatonin receptor agonists. Caution with sedatives or CNS depressants. Monitoring: Sleep quality assessment (PSQI), melatonin levels (salivary DLMO), cognitive function testing. Research Gaps: Independent Western replication of Khavinson group findings. Mechanism of gene expression regulation by tripeptides needs validation. Oral bioavailability data. Comparative efficacy vs. exogenous melatonin for sleep/circadian applications.
Oral/Sublingual
Common Range
10–20 mg per day (typical Russian bioregulator dosing)
Timing
Evening (given pineal/sleep-related target)
Frequency
Daily
Cycling
10–20 day courses, repeated every 3–6 months (standard Khavinson protocol)
Important Note
Part of Khavinson bioregulator protocol. Typically used in short courses rather than continuously. May be combined with Epitalon for synergistic pineal/anti-aging effects. Sublingual administration may improve bioavailability.
Connect with a verified provider offering Pinealon therapy near you.
Anti-Aging
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied primarily by Russian researcher Professor Vladimir Khavinson for its potential telomerase-activating and anti-aging properties. It is one of the more speculative peptides in the longevity space, with most data coming from Russian research institutions.
Immune Modulator (Thymic Peptide)
Thymalin is a polypeptide complex extracted from calf thymus glands, developed at the St. Petersburg Institute of Bioregulation and Gerontology by Dr. Vladimir Khavinson. It is approved in Russia as an immunomodulator and is part of Khavinson's broader bioregulatory peptide research program (alongside Epithalon). It is theorized to restore thymic function and immune competence, particularly in aging and immunocompromised patients.
Sleep / Recovery Peptide
DSIP is a naturally occurring nonapeptide originally isolated from rabbit brain during electrically induced sleep. It modulates sleep architecture, stress response, and pain perception. Despite decades of research since its discovery in 1977, its precise mechanism remains poorly understood, and it has never achieved regulatory approval anywhere. It remains popular in peptide therapy circles for sleep optimization.
Disclaimer: This content is for educational and informational purposes only and does not constitute medical advice. Always consult with a licensed healthcare provider before starting, stopping, or modifying any peptide therapy. PeptideSupplierMatch does not prescribe, sell, or distribute peptides.
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